Ethisterone CAS 434-03-7

Chemical Name

Ethisterone,98%; 17-alpha-ethynyltestosterone; pregneninolone; 17a-ethynyl-17b-hydroxy-4-androsten-3-one; 17a-ethynyl testosterone; anhydrohydroxyprogesterone; ethynyl testosterone; Gestoral;

EINECS

207-096-5

M. F.

C21H28O2

M.W.

312.4458

InChl

InChI=1/C21H28O2/c1-4-21(23)12-9-18-16-6-5-14-13-15(22)7-10-19(14,2)17(16)8-11-20(18,21)3/h1,13,16-18,23H,5-12H2,2-3H3/t16-,17+,18+,19+,20+,21+/m1/s1

Application

Ethisterone (INN, USAN, BAN) (brand names Pranone, Progestoral, Lutocylol, Proluton C, many others), also known as 17α-ethinyltestosterone, pregneninolone, or anhydrohydroxyprogesterone, is a steroidal progestin with androgenic activity which is derived from testosterone and was introduced for medical use in 1939.It was the second progestogen to be marketed (intramuscular progesterone was introduced as Proluton in 1934) and was both the first orally active progestogen and the first progestin (or synthetic progestogen) to be introduced.Although ethisterone has largely been superseded by newer drugs and is now little used, it continues to be available in some countries.Moreover, the 19-nortestosterone progestins, such as norethisterone, are derived from ethisterone and are widely used as hormonal contraceptives and for other indications.

Density

1.13g/cm3

Melting Point

266-273℃

Boiling Point

446.4°C at 760 mmHg

Refractive Index

1.572

Flash Point

190.2°C

Vapour Pressur

7.59E-10mmHg at 25°C